Recent Advances on Sex Hormone-Binding Globulin Regulation by Nutritional Factors: Clinical Implications,Molecular Nutrition & Food Research

当前位置： X-MOL 学术 › Mol. Nutr. Food Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Recent Advances on Sex Hormone-Binding Globulin Regulation by Nutritional Factors: Clinical Implications
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-06-27 , DOI: 10.1002/mnfr.202400020
Laura Brianso-Llort ₁ , Cristina Saéz-Lopez ₁ , Anna Alvarez-Guaita ₁ , Lorena Ramos-Perez ₁ , Cristina Hernandez ₁ , Rafael Simó ₁ , David M Selva ₁

Affiliation

Sex hormone-binding globulin (SHBG) is a homodimeric glycoprotein produced by the human liver and secreted into the systemic circulation where it binds with high affinity sex steroids regulating their availability in blood and accessibility to target tissues. Plasma SHBG levels are altered in metabolic disorders such as obesity, anorexia, and insulin resistance. Several reports have shown that diets in terms of total calories or fat, fiber, or protein content can alter plasma SHBG levels. However, there are many components in a diet that can affect SHBG gene expression in the liver. In order to unravel the molecular mechanisms by which diets regulate SHBG production, it would be necessary to analyze single diet components and/or nutritional factors. This review summarizes the recent advances in identifying different nutritional factors regulating SHBG production and the related molecular mechanism, as well as the clinical implications.

中文翻译：

营养因素调节性激素结合球蛋白的最新进展：临床意义

性激素结合球蛋白 (SHBG) 是一种由人类肝脏产生的同型二聚体糖蛋白，分泌到体循环中，与高亲和力性类固醇结合，调节其在血液中的可用性和对靶组织的可及性。血浆性激素结合球蛋白 (SHBG) 水平会因肥胖、厌食和胰岛素抵抗等代谢紊乱而发生改变。一些报告表明，饮食中的总热量或脂肪、纤维或蛋白质含量可以改变血浆性激素结合球蛋白 (SHBG) 水平。然而，饮食中有许多成分会影响肝脏中SHBG基因的表达。为了揭示饮食调节性激素结合球蛋白产生的分子机制，有必要分析单一饮食成分和/或营养因素。本文总结了调节性激素结合球蛋白产生的不同营养因子及其相关分子机制及其临床意义的最新进展。

更新日期：2024-06-27

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南