An oncolytic adenovirus armed with tumor necrosis factor-α and interleukin-2 was tested in patients with advanced solid tumors. Antitumor effects were observed in both treated and non-treated lesions, leading to long-term survival in some patients. This clinical trial shows the potential of oncolytic virotherapy for patients refractory to standard therapies.

中文翻译：

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双臂溶瘤病毒在晚期实体癌中显示出临床疗效


在晚期实体瘤患者中测试了一种携带肿瘤坏死因子-α 和白细胞介素-2 的溶瘤腺病毒。在治疗和未治疗的病变中均观察到抗肿瘤作用，导致一些患者长期生存。该临床试验显示了溶瘤病毒疗法对于标准疗法难治性患者的潜力。