Background We conducted a global comprehensive literature review of observational studies reporting RSV incidence in adults and determined current evidence gaps. Methods PubMed and Embase were searched for English-language publications (2000-2022) and congress abstracts (2019-2021) reporting RSV incidence rates/cumulative incidence. Cross-sectional studies, case series, and other designs estimating only RSV frequency were excluded. The search included all geographic areas; data were extracted by age group and underlying condition where available. Results 528 potentially relevant records were identified, of which 37 primary studies were relevant to this review. Most evidence was from high-income regions. Approximately two-thirds of the studies reported RSV incidence in the hospital setting. Fifteen studies included or focused exclusively on RSV incidence in adult populations with underlying conditions. Studies varied in their measurement and presentation of incidence. RSV incidence estimates were highly variable within and between geographic regions. Overall, RSV incidence tended to increase with age and was highest in adults with underlying conditions. Conclusion Estimates of RSV incidence are highly variable across populations and geographies. Further population-based studies with well-defined consistent case definitions and surveillance strategies are needed for accurate and comparable estimates of RSV incidence, particularly in the geographic regions identified by the gap analysis.

中文翻译：

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成人 RSV 发病率：观察性研究和关键信息缺口的综合回顾


背景 我们对报告成人 RSV 发病率的观察性研究进行了全球综合文献综述，并确定了当前的证据差距。方法 检索 PubMed 和 Embase 中报告 RSV 发病率/累积发病率的英文出版物（2000-2022 年）和会议摘要（2019-2021 年）。仅估计 RSV 频率的横断面研究、病例系列和其他设计被排除在外。搜索范围包括所有地理区域；数据是按年龄组和可用的基本状况提取的。结果 识别出 528 条潜在相关记录，其中 37 项初步研究与本次综述相关。大多数证据来自高收入地区。大约三分之二的研究报告了医院环境中 RSV 的发病率。十五项研究包括或专门关注患有基础疾病的成年人群中 RSV 的发病率。研究对发病率的测量和呈现各不相同。 RSV 发病率估计在地理区域内和地理区域之间差异很大。总体而言，RSV 发病率随着年龄的增长而增加，并且在患有基础疾病的成年人中最高。结论 RSV 发病率的估计在不同人群和地区之间差异很大。需要进一步基于人群的研究，以及明确一致的病例定义和监测策略，以准确和可比较地估计 RSV 发病率，特别是在差距分析确定的地理区域中。