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Microneedle Patch Loaded with Calcium Peroxide Nanoparticles for Oxygen Healing and Biofilm Inhibition in Diabetic Wound Healing
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2024-06-26 , DOI: 10.1021/acsanm.4c01973 Haijun Shen 1 , Yane Ma 1 , Chun Zhang 1 , Yi Qiao 1 , Jialing Chen 1 , Feng Sun 2
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2024-06-26 , DOI: 10.1021/acsanm.4c01973 Haijun Shen 1 , Yane Ma 1 , Chun Zhang 1 , Yi Qiao 1 , Jialing Chen 1 , Feng Sun 2
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The presence of hypoxics, bacterial infection, and the creation of bacterial biofilms are significant obstacles that hinder the healing of diabetic wounds. Calcium peroxide (CaO2) can be hydrolyzed to produce oxygen (O2) and hydrogen peroxide (H2O2), resulting in the simultaneous creation of oxygen and an antimicrobial effect. However, oxygen delivery is limited by the skin and bacterial biofilm barrier. Herein, we proposed a microneedles patch loading CaO2 nanoparticles (abbreviated as CaO2 NPs@MN). The microneedles can puncture the skin and destroy the biofilm barrier. Meanwhile, upon contact with the biological fluid, the microneedles would be dissolved, and CaO2 NPs would be released into the wound site, further being hydrolyzed to O2 and H2O2 to achieve antibacterial effect and local deep oxygen delivery. Notably, in order to encapsulate CaO2 powders evenly into the microneedle tips and avoid their hydrolysis during the preparation process, we fabricated the nanoscaled CaO2 particles and encapsulated them in microneedles in an ethanol system for the first time. The in vitro experiments demonstrated that CaO2 NPs@MN possessed the desired oxygen delivery and antibacterial effect. Furthermore, the elimination of bacteria, reduction in inflammation, promotion of collagen formation, stimulation of blood vessel growth, and subsequent acceleration of wound healing were observed in in vivo experiments. In conclusion, we provided a simple process for the application of CaO2 in wound healing and also a promising strategy for infected diabetic ulcer treatment.
中文翻译：
载有过氧化钙纳米颗粒的微针贴片，用于糖尿病伤口愈合中的氧气愈合和生物膜抑制
缺氧、细菌感染和细菌生物膜的形成是阻碍糖尿病伤口愈合的重大障碍。过氧化钙（CaO 2 ）可以水解产生氧气（O 2 ）和过氧化氢（H 2 O 2 ），从而同时产生氧气和抗菌作用。然而，氧气输送受到皮肤和细菌生物膜屏障的限制。在此，我们提出了一种负载 CaO 2 纳米颗粒的微针贴片（缩写为 CaO 2 NPs@MN）。微针可以刺穿皮肤并破坏生物膜屏障。同时，与生物体液接触后，微针会溶解，CaO 2 NPs 会释放到伤口部位，进一步水解为 O 2 和 H 2 O 2 达到抗菌作用和局部深部供氧。值得注意的是，为了将 CaO 2 粉末均匀地封装到微针尖端中并避免其在制备过程中水解，我们制备了纳米级 CaO 2 颗粒并将其封装在乙醇中的微针中系统第一次。体外实验表明，CaO 2 NPs@MN 具有所需的氧输送和抗菌作用。此外，在体内实验中还观察到消除细菌、减少炎症、促进胶原蛋白形成、刺激血管生长以及随后加速伤口愈合。总之，我们提供了一种应用 CaO 2 伤口愈合的简单方法，也是治疗感染性糖尿病溃疡的一种有前途的策略。
更新日期：2024-06-26
中文翻译：
载有过氧化钙纳米颗粒的微针贴片，用于糖尿病伤口愈合中的氧气愈合和生物膜抑制
缺氧、细菌感染和细菌生物膜的形成是阻碍糖尿病伤口愈合的重大障碍。过氧化钙（CaO 2 ）可以水解产生氧气（O 2 ）和过氧化氢（H 2 O 2 ），从而同时产生氧气和抗菌作用。然而，氧气输送受到皮肤和细菌生物膜屏障的限制。在此，我们提出了一种负载 CaO 2 纳米颗粒的微针贴片（缩写为 CaO 2 NPs@MN）。微针可以刺穿皮肤并破坏生物膜屏障。同时，与生物体液接触后，微针会溶解，CaO 2 NPs 会释放到伤口部位，进一步水解为 O 2 和 H 2 O 2 达到抗菌作用和局部深部供氧。值得注意的是，为了将 CaO 2 粉末均匀地封装到微针尖端中并避免其在制备过程中水解，我们制备了纳米级 CaO 2 颗粒并将其封装在乙醇中的微针中系统第一次。体外实验表明，CaO 2 NPs@MN 具有所需的氧输送和抗菌作用。此外，在体内实验中还观察到消除细菌、减少炎症、促进胶原蛋白形成、刺激血管生长以及随后加速伤口愈合。总之，我们提供了一种应用 CaO 2 伤口愈合的简单方法，也是治疗感染性糖尿病溃疡的一种有前途的策略。
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