Anti-inflammatory and angiogenesis are two important factors in wound healing. Wound dressings with anti-inflammation and vascularization are essential to address complex interventions, expensive treatments, and uncontrolled release mechanisms. Based on the above considerations, we designed a near-infrared (NIR)-responsive hydrogel dressing, which is composed of mPDA-DFO@LA nanoparticles (mPDA: dopamine hydrochloride nanoparticles, DFO: deferoxamine, LA: lauric acid), valsartan (abbreviated as Va), and dopamine–hyaluronic acid hydrogel. The hydrogel dressing demonstrated injectability, bioadhesive, and photothermal properties. The results indicated the obtained dressing by releasing Va can appropriately regulate macrophage phenotype transformation from M1 to M2, resulting in an anti-inflammatory environment. In addition, DFO encapsulated by LA can be sustainably released into the wound site by NIR irradiation, which further prevents excessive neovascularization. Notably, the results in vivo indicated the mPDA-DFO@LA/Va hydrogel dressing significantly enhanced wound recovery, achieving a healing rate of up to 96% after 11 days of treatment. Therefore, this NIR-responsive hydrogel dressing with anti-inflammation, vascularization, and on-demand programmed drug release will be a promising wound dressing for wound infection.

中文翻译：

---

具有抗炎和促血管生成作用的近红外响应纳米复合水凝胶敷料促进伤口愈合


抗炎和血管生成是伤口愈合的两个重要因素。具有抗炎和血管化作用的伤口敷料对于解决复杂的干预措施、昂贵的治疗和不受控制的释放机制至关重要。基于上述考虑，我们设计了一种近红外（NIR）响应性水凝胶敷料，其由mPDA-DFO@LA纳米颗粒（mPDA：盐酸多巴胺纳米颗粒，DFO：去铁胺，LA：月桂酸）、缬沙坦（简称）组成如Va）和多巴胺透明质酸水凝胶。水凝胶敷料具有可注射性、生物粘附性和光热特性。结果表明，通过释放Va获得的敷料可以适当调节巨噬细胞表型从M1向M2的转变，从而产生抗炎环境。此外，LA包裹的DFO可以通过近红外照射持续释放到伤口部位，进一步防止过度新生血管形成。值得注意的是，体内结果表明 mPDA-DFO@LA/Va 水凝胶敷料显着促进伤口恢复，治疗 11 天后愈合率高达 96%。因此，这种具有抗炎、血管化和按需程序药物释放功能的近红外响应水凝胶敷料将是一种有前途的伤口感染伤口敷料。