Lung-Protective Ventilation for Pediatric Acute Respiratory Distress Syndrome: A Nonrandomized Controlled Trial.,Critical Care Medicine

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Lung-Protective Ventilation for Pediatric Acute Respiratory Distress Syndrome: A Nonrandomized Controlled Trial.
Critical Care Medicine ( IF 7.7 ) Pub Date : 2024-06-26 , DOI: 10.1097/ccm.0000000000006357
Judith Ju Ming Wong _{1,

2} , Hongxing Dang _{3,

4} , Chin Seng Gan ₅ , Phuc Huu Phan ₆ , Hiroshi Kurosawa ₇ , Kazunori Aoki ₇ , Siew Wah Lee _{8,

9} , Jacqueline Soo May Ong ₁₀ , Lijia Fan ₁₀ , Chian Wern Tai ₁₁ , Soo Lin Chuah ₅ , Pei Chuen Lee ₁₁ , Yek Kee Chor ₁₂ , Louise Ngu ₁₂ , Nattachai Anantasit ₁₃ , Chunfeng Liu ₁₄ , Wei Xu ₁₄ , Dyah Kanya Wati _{15,

16} , Suparyatha Ida Bagus Gede _{15,

16} , Muralidharan Jayashree ₁₇ , Felix Liauw ₁₈ , Kah Min Pon ₁₉ , Li Huang ₂₀ , Jia Yueh Chong ₂₁ , Xuemei Zhu ₂₂ , Kam Lun Ellis Hon ₂₃ , Karen Ka Yan Leung ₂₃ , Rujipat Samransamruajkit _{24,

25} , Yin Bun Cheung _{2,

26} , Jan Hau Lee _{1,

2} ,

Affiliation

Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore.
Duke-NUS Medical School, Singapore.
Children's Hospital of Chongqing Medical University, Chongqing, China.
China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China.
Department of Paediatrics, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Vietnam National Children's Hospital, Hanoi, Vietnam.
Hyogo Prefectural Kobe Children's Hospital, Hyogo, Japan.
Sultanah Aminah Hospital, Johor, Malaysia.
Hospital Tengku Ampuan Rahimah, Selangor, Malaysia.
Division of Paediatric Critical Care, National University Hospital, Singapore.
Universiti Kebangsaan Malaysia Specialist Children's Hospital, Kuala Lumpur, Malaysia.
Sarawak General Hospital, Sarawak, Malaysia.
Ramathibodi Hospital, Bangkok, Thailand.
Shengjing Hospital of China Medical University, Liaoning, China.
Pediatric Emergency and Intensive Care Unit, Prof I.G.N.G Ngoerah Hospital, Bali, Indonesia.
Medical Faculty, Udayana University, Bali, Indonesia.
Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Harapan Kita National Women and Children Health Center, Jakarta, Indonesia.
Penang General Hospital, Penang, Malaysia.
Guangzhou Women and Children's Medical Center, Guangdong, China.
Hospital Tunku Azizah Kuala Lumpur, Kuala Lumpur, Malaysia.
Children's Hospital of Fudan University, Shanghai, China.
Paediatric Intensive Care Unit, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China.
Division of Pediatric Critical Care, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Tampere Center for Child, Adolescent and Maternal Health Research, Tampere University, Tampere, Finland.

Despite the recommendation for lung-protective mechanical ventilation (LPMV) in pediatric acute respiratory distress syndrome (PARDS), there is a lack of robust supporting data and variable adherence in clinical practice. This study evaluates the impact of an LPMV protocol vs. standard care and adherence to LPMV elements on mortality. We hypothesized that LPMV strategies deployed as a pragmatic protocol reduces mortality in PARDS.

中文翻译：

小儿急性呼吸窘迫综合征的肺保护性通气：一项非随机对照试验。

尽管建议对小儿急性呼吸窘迫综合征（PARDS）进行肺保护性机械通气（LPMV），但临床实践中缺乏可靠的支持数据和可变的依从性。本研究评估了 LPMV 方案与标准护理以及遵守 LPMV 要素对死亡率的影响。我们假设将 LPMV 策略部署为实用方案可降低 PARDS 的死亡率。

更新日期：2024-06-26

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