Corneal neovascularization (CoNV) is the second leading common cause of vision impairment worldwide and is a blinding pathological alteration brought on by ocular trauma, infection, and other factors. There are some limitations in the treatment of CoNV, hence it's critical to look into novel therapeutic targets. The corneal epithelial barrier, which is the initial barrier of the ocular surface, is an important structure that shields the eye from changes in the internal environment or invasion by the external environment. This study sought to collate evidence on the regulation of corneal epithelial barrier injury on the activation of vascular endothelial cells (VECs), basement membrane (BM) degradation, differentiation, migration, and proliferation of VECs, vascular maturation and stability, and other key processes in CoNV, so as to provide a novel concept for CoNV therapy targeting corneal epithelial barrier repair.

中文翻译：

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恢复角膜上皮屏障功能：角膜新生血管形成的可能靶点


角膜新生血管形成 （CoNV） 是全球视力障碍的第二大常见原因，是由眼外伤、感染和其他因素引起的致盲病理改变。CoNV 的治疗存在一些局限性，因此研究新的治疗靶点至关重要。角膜上皮屏障是眼表的初始屏障，是保护眼睛免受内部环境变化或外部环境侵袭的重要结构。本研究旨在整理角膜上皮屏障损伤对血管内皮细胞 （VECs） 活化、基底膜 （BM） 降解、VECs 分化、迁移和增殖、血管成熟和稳定性以及 CoNV 中其他关键过程的调节证据，从而为针对角膜上皮屏障修复的 CoNV 治疗提供新的概念。