Vaccines are just one part of the broad global effort required Malaria remains a significant global health burden. The World Health Organization’s 2023 malaria report estimates that the number of cases worldwide increased by five million between 2021 and 2022, reaching 249 million.1 Although annual malaria deaths steadily declined between 2000 and 2019, they reached 608 000 in 2022, roughly 32 000 more than pre-pandemic levels. The African region is worst affected, accounting for over 90% of cases and fatalities, mostly among children under 5 years. The current trajectory falls far short of WHO’s ambitious global targets for malaria control to reduce both incidence and mortality by at least 75% by 2025 (relative to 2015 levels), and 90% by 2030.12 Substantial challenges continue to impede progress. Millions of people, particularly in resource limited settings, lack access to essential tools for diagnosis, prevention, and treatment.1 The emergence and spread of drug resistant malaria parasites and insecticide resistant mosquitoes pose a growing threat. Other factors such as climate change, conflict, humanitarian crises, resource shortages, system inefficiencies, and biological developments, including genetic changes in malaria parasites that compromise detection, also …

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我们如何才能使疟疾控制重回正轨？


疫苗只是全球所需要的广泛努力的一部分。疟疾仍然是一个重大的全球健康负担。世界卫生组织的 2023 年疟疾报告估计，2021 年至 2022 年间，全球病例数增加了 500 万例，达到 2.49 亿例。1 尽管 2000 年至 2019 年间，每年因疟疾死亡人数稳步下降，但 2022 年达到 608 万例，比 2022 年增加了约 3.2 万例。高于大流行前的水平。非洲地区受影响最严重，占病例和死亡人数的 90% 以上，其中大多数是 5 岁以下儿童。目前的发展轨迹远远低于世卫组织雄心勃勃的全球疟疾控制目标，即到 2025 年将发病率和死亡率降低至少 75%（相对于 2015 年的水平），到 2030 年降低 90%。12 重大挑战继续阻碍进展。数百万人，特别是在资源有限的环境中，缺乏诊断、预防和治疗的基本工具。1 抗药性疟原虫和抗杀虫剂蚊子的出现和传播构成了日益严重的威胁。其他因素，如气候变化、冲突、人道主义危机、资源短缺、系统效率低下和生物发展，包括影响检测的疟疾寄生虫的基因变化，也……