A convenient and safe cyano source for the nucleophilic 1,4‐addition to enones and 1,2‐addition to imines has been developed, by generating the cyano unit in situ. via the TCT‐assisted dehydration of formamide. This protocol distinguishes itself by transition‐ metal/ligand free conditions, compatibility with 1,4‐/1,2‐addition, readily available substrates and versatile synthetic utilities of the cyanated products.

中文翻译：

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以甲酰胺为氰源的烯酮和亚胺的亲核氰化反应


通过原位生成氰基单元，开发了一种方便且安全的氰基源，用于烯酮的亲核 1,4 加成和亚胺的 1,2 加成。通过 TCT 辅助甲酰胺脱水。该方案的特点是不含过渡金属/配体的条件、与 1,4-/1,2-加成的兼容性、易于获得的底物以及氰化产物的多功能合成用途。