Random difunctionalization of dendrimer surfaces, frequently employed in biological applications, provides the advantage of dual functional groups through a synthetic pathway that is simpler compared to precise difunctionalization. However, is the random difunctionalization as efficient as the precise difunctionalization on the surface of dendrimers? This question is unanswered to date because most dendrimer families face challenges in achieving precise functionalization. Polyphosphorhydrazone (PPH) dendrimers present a unique opportunity to obtain precise difunctionalization at each terminal branching point. The work concerning catalysis we report with PPH dendrimers, whether precisely or randomly functionalized, addresses this question. Across PPH dendrimers, from generations 1 to 3, precise functionalization consistently outperforms random functionalization in terms of efficiency. This finding introduces a novel concept in dendrimer science, emphasizing the superiority of precise over random functionalization methodologies. Introducing a groundbreaking concept in the field of dendrimers.

中文翻译：

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PPH 树枝状大分子双官能化的多种方法，精确与随机：这如何影响催化性能？


树枝状聚合物表面的随机双官能化经常用于生物应用，通过比精确双官能化更简单的合成途径提供双官能团的优势。然而，随机双官能化与树枝状聚合物表面的精确双官能化一样有效吗？这个问题迄今为止尚未得到解答，因为大多数树枝状聚合物家族在实现精确功能化方面面临挑战。聚磷腙 (PPH) 树枝状聚合物提供了在每个末端支化点获得精确双官能化的独特机会。我们报告的有关 PPH 树枝状大分子催化的工作，无论是精确官能化还是随机官能化，都解决了这个问题。在 PPH 树枝状聚合物中，从第 1 代到第 3 代，精确官能化在效率方面始终优于随机官能化。这一发现在树枝状聚合物科学中引入了一个新概念，强调了精确相对于随机功能化方法的优越性。在树枝状聚合物领域引入突破性概念。