A novel strategy for the construction of polysubstituted pyrroles has been developed through the visible-light-induced single-electron reduction of C_Ar–I bonds and the following 1,5-hydrogen atom transfer (HAT) process. This protocol facilitates smooth reactions between cyclic 2-iodobenzoyl amides and internal alkynes bearing electron-withdrawing groups (EWGs), affording a wide range of pyrrole skeletons with diverse substitution patterns. Preliminary mechanistic explorations indicate that the 1,5-HAT process triggered by C_Ar–I activation is crucial to the successful transformation. Scale-up reactions and late-stage modification of natural products further highlight the synthetic potential of this method.

中文翻译：

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可见光介导通过 CAr-I 还原触发 1,5-氢原子转移过程合成多取代吡咯


通过可见光诱导的 C _Ar -I 键的单电子还原和随后的 1,5-氢原子转移 (HAT) 过程，开发了一种构建多取代吡咯的新策略。该方案促进环状 2-碘苯甲酰酰胺和带有吸电子基团 (EWG) 的内部炔烃之间的顺利反应，提供各种具有不同取代模式的吡咯骨架。初步的机制探索表明，C _Ar –I 激活引发的 1,5-HAT 过程对于成功转化至关重要。天然产物的放大反应和后期修饰进一步凸显了该方法的合成潜力。