Background Information on infective endocarditis (IE) caused by Cutibacterium spp. is limited and new Duke-ISCVID criteria have not yet been properly assessed. We examined clinical characteristics, outcomes and performance of diagnostic tests for Cutibacterium valvular and cardiac implantable electronic device-related IE (CIED-IE). Methods Data corresponding to all episodes of Cutibacterium IE recorded from 2008 to 2023 in a prospective national cohort including 46 Spanish hospitals were examined. Possible IE cases were reassessed using the new criteria. The sensitivity of blood cultures, valvular and CIED cultures, and PCR of the 16SrRNA gene and sequencing (16SPCR) was evaluated. Results There were 67/6,692 (1%) episodes of IE caused by Cutibacterium spp., 85% affecting men. Of these, 50 were valve-related (45 prosthetic, 5 native) and 17 CIED-related. The new criteria identified 8 additional cases and reclassified 15 as definite IE. Intracardiac complications (abscess, pseudoaneurysm, perforation or intracardiac fistula) occurred in 23/50 (46%) valvular IE episodes, leading to 18% mortality, and up to 40% mortality if surgery was indicated but could not be performed. All CIED-IE cases underwent device removal and no deaths were recorded. Positive diagnosis rates for blood cultures, valve/device cultures and 16SPCR were 52%, 70% and 82%, respectively. Conclusion Cutibacterium IE is a rare yet potentially life-threatening condition that warrants a high index of suspicion in men with endovascular prosthetic material. The new Duke-ISCVID criteria and molecular techniques are useful for its diagnosis. Considering a significant complication rate, cardiac surgery and removal of CIEDs play a key role in reducing mortality.

中文翻译：

---

皮肤杆菌属瓣膜和心脏装置相关的感染性心内膜炎：来自 GAMES 前瞻性队列的当代数据（2008-2023）


由皮肤杆菌引起的感染性心内膜炎（IE）的背景信息。是有限的，新的杜克大学 ISCVID 标准尚未得到适当的评估。我们检查了瓣膜皮肤杆菌和心脏植入电子设备相关 IE (CIED-IE) 的临床特征、结果和诊断测试性能。方法 对包括 46 家西班牙医院的前瞻性全国队列中 2008 年至 2023 年记录的所有 Cutibacter IE 发作相对应的数据进行了检查。使用新标准重新评估了可能的 IE 案例。评估了血培养、瓣膜和 CIED 培养以及 16SrRNA 基因 PCR 和测序 (16SPCR) 的敏感性。结果 67/6,692 (1%) 例由皮肤杆菌引起的 IE 发作，其中 85% 影响男性。其中，50 例与瓣膜相关（45 例为假体，5 例为自体瓣膜），17 例与 CIED 相关。新标准又确定了 8 例病例，并将 15 例重新分类为明确的 IE。 23/50 (46%) 的瓣膜 IE 发作会出现心内并发症（脓肿、假性动脉瘤、穿孔或心内瘘），导致 18% 的死亡率，如果需要手术但无法进行，则死亡率高达 40%。所有 CIED-IE 病例均接受了装置移除，没有死亡记录。血培养、瓣膜/器械培养和 16SPCR 的阳性诊断率分别为 52%、70% 和 82%。结论 皮肤杆菌 IE 是一种罕见但可能危及生命的疾病，对于使用血管内假体材料的男性需要高度怀疑。新的 Duke-ISCVID 标准和分子技术对其诊断很有用。考虑到显着的并发症发生率，心脏手术和 CIED 切除在降低死亡率方面发挥着关键作用。