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Vaccination prevents cognitive impairment after breakthrough infection with SARS-CoV-2
Nature Immunology ( IF 27.7 ) Pub Date : 2024-06-25 , DOI: 10.1038/s41590-024-01869-y


IL-1R1 signaling in neural stem cells reduces hippocampal neurogenesis in adult mice, potentially affecting learning and memory. Using a new mouse model, we report that IL-1β drives cognitive impairment after infection with SARS-CoV-2, and that IL-1β-driven cognitive impairment can be prevented by vaccination, even in cases of breakthrough infection.

中文翻译:


疫苗接种可预防突破性感染 SARS-CoV-2 后的认知障碍



神经干细胞中的 IL-1R1 信号传导会减少成年小鼠的海马神经发生,可能影响学习和记忆。使用新的小鼠模型,我们报告说,IL-1β 在感染 SARS-CoV-2 后会导致认知障碍,并且即使在突破性感染的情况下,也可以通过疫苗接种来预防 IL-1β 驱动的认知障碍。
更新日期:2024-06-25
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