Model matchmaking via the Solve-RD Rare Disease Models & Mechanisms Network (RDMM-Europe),Lab Animal

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Model matchmaking via the Solve-RD Rare Disease Models & Mechanisms Network (RDMM-Europe)
Lab Animal ( IF 5.9 ) Pub Date : 2024-06-24 , DOI: 10.1038/s41684-024-01395-2
Kornelia Ellwanger ₁ , Julie A Brill _{2,

3} , Elke de Boer _{4,

5} , Stephanie Efthymiou ₆ , Ype Elgersma ₇ , Marynelle Icmat _{2,

3} , François Lecoquierre ₈ , Amanda G Lobato _{9,

10,

11} , Manuela Morleo _{12,

13} , Michela Ori ₁₄ , Ashleigh E Schaffer ₁₅ , Antonio Vitobello _{16,

17} , Sara Wells ₁₈ , Binnaz Yalcin ₁₉ , R Grace Zhai _{9,

11} , Marc Sturm ₁ , Birte Zurek ₁ , Holm Graessner ₁ , Eva Bermejo-Sánchez ₂₀ , Teresinha Evangelista ₂₁ , Nicoline Hoogerbrugge ₄ , Vincenzo Nigro _{12,

13} , Rebecca Schüle ₂₂ , Alain Verloes ₂₃ , Han Brunner ₄ , Philippe M Campeau ₂₄ , Paul Lasko ₂₅ , Olaf Riess ₁

Affiliation

Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
The Hospital for Sick Children, Toronto, Ontario, Canada.
Department of Molecular Genetics, University of Toronto, Ontario, Canada.
Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Department of Neuromuscular Disorders, Queen Square Institute of Neurology, University College London, London, UK.
Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, the Netherlands.
Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics, FHU G4 Génomique, Rouen, France.
Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.
Graduate Program in Human Genetics and Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Neurology, University of Chicago, Chicago, IL, USA.
Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli (Na), Italy.
Department of Precision Medicine, University of Campania Luigi Vanvitelli, Napoli, Italy.
Department of Biology, University of Pisa, Pisa, Italy.
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
INSERM-Université de Bourgogne UMR1231 GAD «Génétique Des Anomalies du Développement», FHU-TRANSLAD, UFR Des Sciences de Santé, Dijon, France.
Dijon University Hospital- UF innovation en diagnostic génomique, Dijon, France.
The Mary Lyon Centre at MRC Harwell, Harwell Science Campus, Oxon, UK.
Inserm Unit 1231, University of Bourgogne Franche-Comté, Dijon, France.
Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Sorbonne Université, Inserm, Institut de Myologie, Centre de Recherche en Myologie, Paris, France.
Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.
Department of Genetics, Assistance Publique-Hôpitaux de Paris - Université de Paris, Robert DEBRE University Hospital, Paris, France.
Department of Pediatrics, CHU Sainte-Justine and University of Montreal, Montreal, Quebec, Canada.
Department of Biology, McGill University, Montreal, Quebec, Canada.

In biomedical research, particularly for rare diseases (RDs), there is a critical need for model organisms to unravel the mechanistic basis of diseases, perform biomarker studies and develop potential therapeutic interventions. Within Solve-RD, an EU-funded research project with the aim of solving large numbers of previously unsolved RDs, the European Rare Disease Models & Mechanisms Network (RDMM-Europe) has been established.

中文翻译：

通过 Solve-RD 罕见疾病模型和机制网络（RDMM-欧洲）进行模型匹配

在生物医学研究中，特别是罕见疾病 (RD) 的研究中，迫切需要模型生物来揭示疾病的机制基础、进行生物标志物研究并开发潜在的治疗干预措施。 Solve-RD 是一个由欧盟资助的研究项目，旨在解决大量以前未解决的 RD，在该项目中，欧洲罕见病模型和机制网络 (RDMM-Europe) 已经建立。

更新日期：2024-06-25

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