The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed light on previously underappreciated biological mechanisms that promote diseases. With these insights, novel biomarkers and innovative combination therapies can be used to address challenging and difficult to treat disease states. This review highlights key mechanisms that epigenetic writers, erasers, readers, and remodelers control, as well as their connection with disease states and recent advances in associated epigenetic therapies.

中文翻译：

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表观遗传调节剂提供了了解疾病和治疗机会的途径


表观遗传调节剂（写入器、擦除器、读取器和重塑器）的发现揭示了先前未被充分认识的促进疾病的生物机制。有了这些见解，新型生物标志物和创新的联合疗法可用于解决具有挑战性和难以治疗的疾病状态。这篇综述重点介绍了表观遗传写入者、擦除者、阅读者和重塑者控制的关键机制，以及它们与疾病状态的联系以及相关表观遗传疗法的最新进展。