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Scarring In Utero: An Attempt to Validate With Data Unconfounded by Migration and Medical Care.
Epidemiology ( IF 4.7 ) Pub Date : 2024-06-24 , DOI: 10.1097/ede.0000000000001740
Ralph Catalano 1 , Jason Bonham 2 , Alison Gemmill 3 , Tim Bruckner 2
Affiliation  

"Scarring in utero" posits that populations exposed to injurious stressors yield birth cohorts that live shorter lives than expected from history. This argument implies a positive historical association between period life expectancy (i.e., average age at death in year t) and cohort life expectancy (i.e., average lifespan of persons born in year t). Tests of the argument have not produced consistent results and appear confounded by autocorrelation, migration, and access to medical care. Here we test whether, as predicted by scarring in utero, sex-specific period and cohort life expectancy appear positively related among Swedes born from 1751 through 1800. If scarring has ever influenced longevity, we should detect signals of its effects in these cohorts because, unlike other populations with known life span, they aged in place and unlikely benefitted from increased access to efficacious medical care.

中文翻译:


子宫内的疤痕:尝试用不受移民和医疗保健影响的数据进行验证。



“子宫内的疤痕”假设,暴露于有害压力源的人群所产生的出生群体的寿命比历史预期的要短。这一论点暗示了一段时期的预期寿命(即,t 年的平均死亡年龄)和队列预期寿命(即,t 年出生的人的平均寿命)之间存在正向的历史关联。对这一论点的检验并未产生一致的结果,并且似乎因自相关、移民和获得医疗保健的机会而混淆。在这里,我们测试是否如子宫内疤痕所预测的那样,在 1751 年至 1800 年出生的瑞典人中,特定性别的时期和队列预期寿命似乎呈正相关。如果疤痕曾经影响过寿命,我们应该在这些队列中检测到其影响的信号,因为,与其他已知寿命的人群不同,他们在原地老龄化,不太可能从增加获得有效医疗服务的机会中受益。
更新日期:2024-06-24
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