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Albumin Versus Balanced Crystalloid for the Early Resuscitation of Sepsis: An Open Parallel-Group Randomized Feasibility Trial. The ABC-Sepsis Trial.
Critical Care Medicine ( IF 7.7 ) Pub Date : 2024-06-24 , DOI: 10.1097/ccm.0000000000006348 Alasdair J Gray 1, 2 , Katherine Oatey 3 , Julia Grahamslaw 1 , Sîan Irvine 3 , John Cafferkey 1 , Titouan Kennel 3 , John Norrie 3 , Tim Walsh 2 , Nazir Lone 2 , Daniel Horner 4, 5 , Andy Appelboam 6 , Peter Hall 3 , Richard J E Skipworth 7 , Derek Bell 8 , Kevin Rooney 9, 10 , Manu Shankar-Hari 11 , Alasdair R Corfield 10, 12 ,
Critical Care Medicine ( IF 7.7 ) Pub Date : 2024-06-24 , DOI: 10.1097/ccm.0000000000006348 Alasdair J Gray 1, 2 , Katherine Oatey 3 , Julia Grahamslaw 1 , Sîan Irvine 3 , John Cafferkey 1 , Titouan Kennel 3 , John Norrie 3 , Tim Walsh 2 , Nazir Lone 2 , Daniel Horner 4, 5 , Andy Appelboam 6 , Peter Hall 3 , Richard J E Skipworth 7 , Derek Bell 8 , Kevin Rooney 9, 10 , Manu Shankar-Hari 11 , Alasdair R Corfield 10, 12 ,
Affiliation
International guidelines recommend IV crystalloid as the primary fluid for sepsis resuscitation, with 5% human albumin solution (HAS) as the second line. However, it is unclear which fluid has superior clinical effectiveness. We conducted a trial to assess the feasibility of delivering a randomized controlled trial comparing balanced crystalloid against 5% HAS as sole early resuscitation fluid in patients with sepsis presenting to hospital.
中文翻译:
白蛋白与平衡晶体用于脓毒症早期复苏:一项开放平行组随机可行性试验。 ABC-败血症试验。
国际指南推荐静脉注射晶体液作为脓毒症复苏的主要液体,5%人白蛋白溶液(HAS)作为第二线。然而,尚不清楚哪种液体具有更好的临床效果。我们进行了一项试验,以评估进行随机对照试验的可行性,比较平衡晶体与 5% HAS 作为脓毒症入院患者的唯一早期复苏液。
更新日期:2024-06-24
中文翻译:
白蛋白与平衡晶体用于脓毒症早期复苏:一项开放平行组随机可行性试验。 ABC-败血症试验。
国际指南推荐静脉注射晶体液作为脓毒症复苏的主要液体,5%人白蛋白溶液(HAS)作为第二线。然而,尚不清楚哪种液体具有更好的临床效果。我们进行了一项试验,以评估进行随机对照试验的可行性,比较平衡晶体与 5% HAS 作为脓毒症入院患者的唯一早期复苏液。