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Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses
Science Immunology ( IF 17.6 ) Pub Date : 2024-06-14 , DOI: 10.1126/sciimmunol.adp4474
Stephanie A. Ragland 1 , Jonathan C. Kagan 1
Affiliation  

Single-stranded DNA containing CGT/A motifs binds to the helicase domain of Schlafen 11 (SLFN11) to initiate cell death and cytokine production via SLFN11 ribonuclease activity (see related Research Article by Zhang et al. ).

中文翻译:


唤醒沉睡的巨人:单链 DNA 结合 Schlafen 11 启动先天免疫反应



含有 CGT/A 基序的单链 DNA 与 Schlafen 11 (SLFN11) 的解旋酶结构域结合,通过 SLFN11 核糖核酸酶活性启动细胞死亡和细胞因子产生(请参阅Zhang 等人的相关研究文章)。
更新日期:2024-06-14
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