Gold-Catalyzed C–N Cross-Coupling Reactions of Aryl Iodides with Alkyl Nitriles or Silver Cyanate,Organic Letters

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Gold-Catalyzed C–N Cross-Coupling Reactions of Aryl Iodides with Alkyl Nitriles or Silver Cyanate
Organic Letters ( IF 4.9 ) Pub Date : 2024-06-24 , DOI: 10.1021/acs.orglett.4c01538
Hongyan Liu ₁ , Bo Xu ₁

Affiliation

We have gold-catalyzed C–N cross-couplings of aryl iodides with aliphatic nitriles. Although nitriles are usually challenging nitrogen cross-coupling partners, they could be activated by base-mediated deprotonation and isomerization. The method utilizes widely available substrates in moderate to good yields to provide various N-aryl compounds. In addition, a similar strategy could be extended to the cross-couplings of aryl iodides with silver cyanate. The protocol features high humidity/air tolerance and works inter- and intramolecularly.

中文翻译：

金催化芳基碘化物与烷基腈或氰酸银的 C-N 交叉偶联反应

我们有金催化的芳基碘化物与脂肪腈的 C-N 交叉偶联。尽管腈通常是具有挑战性的氮交叉偶联伙伴，但它们可以通过碱介导的去质子化和异构化来激活。该方法利用广泛可用的底物，以中等至良好的产率提供各种N-芳基化合物。此外，类似的策略可以扩展到芳基碘化物与氰酸银的交叉偶联。该方案具有高湿度/空气耐受性，可在分子间和分子内发挥作用。

更新日期：2024-06-24

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