This study highlights the biological efficiency of pyrimido[4,5‐b]quinolines as inhibitors of cancer cell growth and antioxidants and anti‐inflammatory properties, etc. Recent research studies have revealed their promising biological activity to inhibit the growth of many disease‐causing yeasts, fungi, and bacteria. The structural composition greatly affects the biological effectiveness, as these compounds exceed the value of some standard compounds against pathogenic microbes. The antioxidant potential of these derivatives is also explored. Several glycosylated and non‐glycosylated derivatives exhibited potent free radical scavenging activity and protected against DNA damage, exceeding reference standards in some cases. Furthermore, the review examines the anti‐inflammatory and analgesic properties of pyrimidoquinoline derivatives. Studies suggest their efficacy is comparable to known drugs like diclofenac and aspirin in carrageenan‐induced paw edema and hot plate tests. Pyrimidoquinoline derivatives also demonstrate promising anticancer activity. While some have minimal effects, others exhibit notable activity against various human cancer cell lines. This review documents over two decades of research, covering the period from 2000 to 2024. Overall, pyrimidoquinoline derivatives signify an auspicious class of compounds with therapeutic potential across various areas. Further research is necessary to elucidate their mechanisms of action, optimize their efficacy and selectivity, and assess their safety profiles for clinical development.

中文翻译：

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嘧啶并[4,5-b]喹啉支架的生物学重要性的最新进展和发展


这项研究强调了嘧啶并[4,5-b]喹啉作为癌细胞生长抑制剂、抗氧化剂和抗炎特性等的生物效率。最近的研究表明，它们具有抑制许多致病细胞生长的良好生物活性。酵母、真菌和细菌。结构组成极大地影响了生物有效性，因为这些化合物超过了一些标准化合物对抗病原微生物的价值。还探索了这些衍生物的抗氧化潜力。几种糖基化和非糖基化衍生物表现出有效的自由基清除活性并防止 DNA 损伤，在某些情况下超过了参考标准。此外，该综述还研究了嘧啶喹啉衍生物的抗炎和镇痛特性。研究表明，在角叉菜胶引起的爪子水肿和热板试验中，它们的功效与双氯芬酸和阿司匹林等已知药物相当。嘧啶并喹啉衍生物也表现出有前景的抗癌活性。虽然有些效果很小，但另一些则对各种人类癌细胞系表现出显着的活性。这篇综述记录了从 2000 年到 2024 年二十多年的研究。总体而言，嘧啶喹啉衍生物代表了一类在各个领域具有治疗潜力的吉祥化合物。需要进一步的研究来阐明其作用机制，优化其功效和选择性，并评估其临床开发的安全性。