The introduction of trifluoromethylsulfinyl group into the required target molecules has become an indispensable strategy for pharmaceutical chemists to improve the success of new drug discovery. Compared with the indirect methods, direct trifluoromethylsulfinylation by employing available trifluoromethylsulfinylating reagents is an important and elegant strategy for the rapid assembly of valuable CF3S(O)‐derived organic molecules. This review focuses on the recent synthetic approaches and future perspectives of trifluoromethylsulfinyl compounds based on the indirect and direct methods in this area. These transformations proceed effectively with high yields and good functional group compatibility under mild conditions.

中文翻译：

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三氟甲基亚磺酰基化合物：最新合成方法和未来展望


将三氟甲基亚磺酰基引入所需的靶分子中已成为药物化学家提高新药发现成功率不可或缺的策略。与间接方法相比，使用现有的三氟甲基亚磺酰化试剂进行直接三氟甲基亚磺酰化是快速组装有价值的CF3S(O)衍生有机分子的重要而优雅的策略。本文重点介绍了基于间接和直接方法的三氟甲基亚磺酰基化合物的最新合成方法和未来展望。这些转化在温和条件下有效地进行，具有高产率和良好的官能团相容性。