Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host–microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases.

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金属免疫疗法的发展策略

金属离子在免疫途径的调节中起着至关重要的作用。事实上，金属药物作为多种疾病的有效治疗方法有着悠久的历史。在这里，我们认为金属离子与免疫系统中涉及的分子和细胞相互作用的调节形成了一类新型免疫疗法的基础。通过研究金属离子如何调节先天性和适应性免疫系统以及宿主与微生物群的相互作用，我们讨论了开发此类金属免疫疗法来治疗癌症和其他免疫相关疾病的策略。