Abstract

N-Benzenesulfonyl amino acid esters have drawn much attention due to their pharmacological and biological activity. Herein, a facile and effective one-pot approach to N-benzenesulfonyl amino acid esters has been developed, and 16 compounds have been obtained in excellent yields (90–95%) in a short time (9–14 min) using 4-bromobenzenethiol and amino acid esters as starting materials. Significantly, methyl 2-(4-bromoben­zene­sulfon­amido)acetate (3a) could enhance the proline content of soybean in response to excess cadmium in a way similar to the plant hormone abscisic acid.

中文翻译：

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N-苯磺酰氨基酸酯的一锅法可提高脯氨酸含量以应对过量镉

 抽象的

N-苯磺酰氨基酸酯因其药理和生物活性而备受关注。在此，开发了一种简便有效的一锅法制备 N-苯磺酰氨基酸酯，并使用 4-溴苯硫酚在短时间内（9-14 分钟）以优异的产率（90-95%）获得了 16 种化合物和氨基酸酯作为起始原料。值得注意的是，2-(4-溴苯磺酰胺)乙酸甲酯 (3a) 可以通过与植物激素脱落酸类似的方式提高大豆对过量镉的脯氨酸含量。