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ANT2: the first mammalian mitochondrial RNA transport translocon
Cell Research ( IF 28.1 ) Pub Date : 2024-06-24 , DOI: 10.1038/s41422-024-00994-5 Huanhuan Zhu 1 , Weiqiang Lin 2 , Aifu Lin 2, 3
中文翻译：
ANT2：第一个哺乳动物线粒体 RNA 转运易位子
更新日期：2024-06-24
Cell Research ( IF 28.1 ) Pub Date : 2024-06-24 , DOI: 10.1038/s41422-024-00994-5 Huanhuan Zhu 1 , Weiqiang Lin 2 , Aifu Lin 2, 3
Affiliation
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Despite the crucial roles of mitochondrial RNA transport in maintaining mitochondrial functionality, how mitochondrial RNAs are transported across mitochondrial membranes remains largely unknown. In a recent work published in Cell Research, Wang et al. identified adenine nucleotide translocase-2 as the first mammalian mitochondrial RNA translocon using a series of innovative biochemical systems and revealed its regulatory role in innate immunity triggered by mitochondrial double-stranded RNA efflux.
中文翻译：
ANT2：第一个哺乳动物线粒体 RNA 转运易位子
尽管线粒体 RNA 运输在维持线粒体功能方面发挥着至关重要的作用，但线粒体 RNA 如何跨线粒体膜运输仍然很大程度上未知。 Wang 等人最近在《细胞研究》杂志上发表了一篇论文。利用一系列创新的生化系统将腺嘌呤核苷酸转位酶-2鉴定为第一个哺乳动物线粒体RNA转位子，并揭示了其在线粒体双链RNA流出触发的先天免疫中的调节作用。
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