Novel herbicide flusulfinam: absolute configuration, enantioseparation, enantioselective bioactivity, toxicity and degradation in paddy soils,Pest Management Science

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Novel herbicide flusulfinam: absolute configuration, enantioseparation, enantioselective bioactivity, toxicity and degradation in paddy soils
Pest Management Science ( IF 3.8 ) Pub Date : 2024-06-21 , DOI: 10.1002/ps.8251
Shiling Liu ₁ , Xiaoli Li ₁ , Junqi Zhu ₁ , Liying Liang ₁ , Heng Zhang ₁ , Ying Liao ₁ , Jiaheng Li ₁ , Lei Lian ₂ , Huihua Tan ₁ , Feng Zhao ₁

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BACKGROUNDFlusulfinam, a novel chiral herbicide, effectively controls Echinochloa crusgalli and Digitaria sanguinalis in paddy fields, indicating significant potential for practical agricultural applications. However, limited information is available on flusulfinam from a chiral perspective. A comprehensive evaluation of the enantiomeric levels of flusulfinam was performed.RESULTSTwo enantiomers, R‐(+)‐ and S‐(−)‐flusulfinam, were separately eluted using a Chiralcel OX‐RH column. The bioactivity of R‐flusulfinam against the two was 1.4–3.1 fold that of Rac‐flusulfinam against two weed species. R‐flusulfinam toxicity to Danio rerio larvae and Selenastrum capricornutumwere was 0.8‐ and 3.0‐fold higher than Rac‐flusulfinam, respectively. Degradation experiments were conducted using soil samples from four Chinese provinces. The findings indicated that S‐flusulfinam (half‐life T1/2 = 40.8 days) exhibits preferential degradation than R‐flusulfinam (T1/2 = 46.2–57.8 days) in the soils of three provinces. Under anaerobic conditions, soil from Anhui exhibited preferential degradation of R‐flusulfinam (T1/2 = 46.2 days) over S‐flusulfinam (T1/2 = 63 days). Furthermore, two hydrolysis products of flusulfinam (M299 and M100) are proposed for the first time.CONCLUSIONThe enantioselective bioactivity, toxicity and degradation of flusulfinam were investigated. Our findings indicate that R‐flusulfinam is an extremely effective and low‐toxicity enantiomer for the tested species. The soil degradation test indicated that the degradation of flusulfinam was accelerated by higher organic matter content and lower soil pH. Furthermore, microbial communities may play a crucial role in driving the enantioselective degradation processes. This study lays the groundwork for the systematic evaluation of flusulfinam from an enantiomeric perspective. © 2024 Society of Chemical Industry.

更新日期：2024-06-21

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