In recent years, the registrations for a number of commercial insecticides utilized for piercing/sucking insects have been cancelled or restricted. To meet this growing need for new hemipteran controlling agrochemicals, we discovered a 2‐(pyridin‐3‐yl)‐thiazole compound, with limited insecticidal activity against cotton/melon aphid (Aphis gossypii). The 2‐(pyridin‐3‐yl)‐thiazole moiety offered us a basis to pursue the bicyclic 2‐(pyridin‐3‐yl)‐2H‐indazole carboxamides. Evaluation of such 2‐(pyridin‐3‐yl)‐2H‐indazole carboxamides revealed that even analogs containing only simple alkyl amides attached at the 4 or 5 positions possess promising insecticidal activity. Extensive optimization of this novel class of 2‐(pyridin‐3‐yl)‐2H‐indazole carboxamides led to identifying indazapyroxamet for commercial development. © 2024 Society of Chemical Industry.

中文翻译：

---

茚扎吡咯沙特的发现：一种针对刺吸式昆虫的新型 3-吡啶基杀虫剂a


近年来，一些用于刺吸式昆虫的商业杀虫剂的登记被取消或限制。为了满足对新型半翅目控制农用化学品日益增长的需求，我们发现了一种 2-(吡啶-3-基)-噻唑化合物，其对棉/瓜蚜 (Aphis gossypii) 的杀虫活性有限。 2-(吡啶-3-基)-噻唑部分为我们研究双环2-(吡啶-3-基)-2H-吲唑甲酰胺提供了基础。对此类 2-(吡啶-3-基)-2H-吲唑甲酰胺的评估表明，即使仅包含在 4 或 5 位连接的简单烷基酰胺的类似物也具有良好的杀虫活性。对这类新型 2-(吡啶-3-基)-2H-吲唑甲酰胺的广泛优化导致确定了吲扎吡沙美用于商业开发。 © 2024 化学工业协会。