Telosma mosaic virus (TelMV, Potyvirus, Potyviridae) is an emerging viral pathogen that threatens passion fruit plantations worldwide. However, an efficient strategy for controlling such a virus is not yet available. Cross protection is a phenomenon in which pre-infection of a plant with one mild strain prevents or delays subsequent infection by the same or closely related virus. HC-Pro is the potyviral encoded multifunctional protein involved in several steps of viral infection, including multiplication, movement, transmission and RNA silencing suppression. In this study, we tested whether it is possible to generate attenuated viral strains capable of conferring protection against severe TelMV infection by manipulating the HC-Pro gene.

中文翻译：

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突变夜蛾花叶病毒 (TelMV) HC-Pro 蛋白 FRNK 基序内的精氨酸残基可减弱病毒感染，并有效保护百香果 (Passiflora edulis) 免受 TelMV 的侵害


Telosma 花叶病毒（TelMV、Potyvirus、Potyviridae）是一种新兴的病毒病原体，威胁着全世界的百香果种植园。然而，目前还没有控制此类病毒的有效策略。交叉保护是一种现象，其中用一种温和菌株预先感染植物可以防止或延迟相同或密切相关的病毒的后续感染。 HC-Pro是马铃薯病毒编码的多功能蛋白，参与病毒感染的多个步骤，包括增殖、运动、传播和RNA沉默抑制。在这项研究中，我们测试了是否有可能通过操纵 HC-Pro 基因来产生能够提供针对严重 TelMV 感染的保护的减毒病毒株。