A simple and efficient salicylaldehyde‐promoted cobalt‐catalyzed protocol for the C‐H alkoxylation of aromatic amides by employing primary alcohols as the coupling partner has been developed. This method utilizes a 8‐aminoquinoline moiety as the directing group and successfully achieves the ortho‐C‐H alkoxylation in moderate to good yields under mild conditions. This protocol features excellent functional tolerance and broad substrate scope including natural product. In addition, the directing group could be easily removed as well.

中文翻译：

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水杨醛-Co(II)配合物催化芳香酰胺的温和C-H烷氧基化


开发了一种简单高效的水杨醛促进的钴催化方案，通过使用伯醇作为偶联伙伴来进行芳香酰胺的 C-H 烷氧基化。该方法利用8-氨基喹啉部分作为导向基团，在温和条件下成功实现了邻位C-H烷氧基化，产率中等至良好。该方案具有出色的功能耐受性和广泛的底物范围（包括天然产物）。此外，指挥小组也可以很容易地被移除。