Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated With Psychopathology Across Independent Cohorts,Biological Psychiatry

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Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated With Psychopathology Across Independent Cohorts
Biological Psychiatry ( IF 9.6 ) Pub Date : 2024-06-21 , DOI: 10.1016/j.biopsych.2024.06.011
Haley R Wang ₁ , Zhen-Qi Liu ₂ , Hajer Nakua ₃ , Catherine E Hegarty ₄ , Melanie Blair Thies ₅ , Pooja K Patel ₆ , Charles H Schleifer ₇ , Thomas P Boeck ₄ , Rachel A McKinney ₄ , Danielle Currin ₄ , Logan Leathem ₄ , Pamela DeRosse ₈ , Carrie E Bearden ₁ , Bratislav Misic ₂ , Katherine H Karlsgodt ₁

Affiliation

Department of Psychology, University of California, Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
Montréal Neurological Institute, McGill University, Montréal, Québec, Canada.
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
Department of Psychology, University of California, Los Angeles, Los Angeles, California.
Department of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California; Desert Pacific Mental Illness Research, Education, and Clinical Center Greater Los Angeles VA Healthcare System, Los Angeles, California.
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Department of Psychology, Stony Brook University, Stony Brook, New York.

Patients with early psychosis (EP) (within 3 years after psychosis onset) show significant variability, which makes predicting outcomes challenging. Currently, little evidence exists for stable relationships between neural microstructural properties and symptom profiles across EP diagnoses, which limits the development of early interventions.

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