The role of a novel secretory peptidoglycan recognition protein with antibacterial ability from the Chinese Oak Silkworm Antheraea pernyi in humoral immunity,Insect Biochemistry and Molecular Biology

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The role of a novel secretory peptidoglycan recognition protein with antibacterial ability from the Chinese Oak Silkworm Antheraea pernyi in humoral immunity
Insect Biochemistry and Molecular Biology ( IF 3.2 ) Pub Date : 2024-06-14 , DOI: 10.1016/j.ibmb.2024.104151
Xutong Duan ₁ , Ting Fu ₁ , Chang Liu ₂ , Fuhui Wang ₁ , Chengbao Liu ₁ , Lin Zhao ₁ , JinZhu Yu ₁ , Xialu Wang ₂ , Rong Zhang ₁

Affiliation

Peptidoglycan recognition proteins (PGRPs) are a family of pattern recognition receptors that play a critical role in the immune response of invertebrates and vertebrates. Herein, the short PGRP-D gene was cloned from the model lepidopteran Quantitative PCR (qPCR) confirmed that PGRP-D is an immune-related protein and that the expression of PGRP-D can be induced by microorganisms. PGRP-D is a broad-spectrum pattern recognition protein that activates the prophenoloxidase cascade activation system and promotes the agglutination of microbial cells. Likely due to its amidase activity, PGRP-D can inhibit the growth of and . In addition, we demonstrated for the first time that zinc ions, as important metal coenzymes, could promote multiple functions of PGRP-D but not its amidase activity.

中文翻译：

柞蚕新型分泌型抗菌肽聚糖识别蛋白在体液免疫中的作用

肽聚糖识别蛋白 (PGRP) 是一个模式识别受体家族，在无脊椎动物和脊椎动物的免疫反应中发挥着关键作用。本文从鳞翅目模型中克隆了短PGRP-D基因，定量PCR（qPCR）证实PGRP-D是一种免疫相关蛋白，并且微生物可以诱导PGRP-D的表达。 PGRP-D是一种广谱模式识别蛋白，可激活原酚氧化酶级联激活系统并促进微生物细胞的凝集。可能由于其酰胺酶活性，PGRP-D 可以抑制和的生长。此外，我们首次证明锌离子作为重要的金属辅酶，可以促进PGRP-D的多种功能，但不能促进其酰胺酶活性。

更新日期：2024-06-14

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