, widely recognized as a medicinal and edible mushroom in East Asia, contains a variety of bioactive compounds, including cordycepin (COR), pentostatin (PTN) and other high-value compounds. This review explores the potential of developing as a cell factory for the production of high-value chemicals and nutrients. This review comprehensively summarizes the fermentation advantages, metabolic networks, expression elements, and genome editing tools specific to and discusses the challenges and barriers to further research on across various fields, including computational biology, existing DNA elements, and genome editing approaches. This review aims to describe specific and promising opportunities for the in-depth study and development of as a new chassis cell. Additionally, to increase the practicability of this review, examples of the construction of cell factories are provided, and promising strategies for synthetic biology development are illustrated.

中文翻译：

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蛹虫草：代谢工程的新型蘑菇平台


在东亚被广泛认为是药食两用的蘑菇，含有多种生物活性化合物，包括虫草素（COR）、喷司他丁（PTN）等高价值化合物。本综述探讨了发展为生产高价值化学品和营养素的细胞工厂的潜力。这篇综述全面总结了发酵优势、代谢网络、表达元件和基因组编辑工具，并讨论了跨各个领域进一步研究的挑战和障碍，包括计算生物学、现有DNA元件和基因组编辑方法。本综述旨在描述深入研究和开发新型底盘单元的具体且有前景的机会。此外，为了提高本综述的实用性，提供了细胞工厂构建的例子，并说明了合成生物学发展的有前景的策略。