Stimulus-responsive delivery systems allow controlled, highly regulated, and efficient delivery of various cargos while minimizing side effects. Owing to the unique properties of nucleic acids, including the ability to adopt complex structures by base pairing, their easy synthesis, high specificity, shape memory, and configurability, they have been employed in autonomous molecular motors, logic circuits, reconfigurable nanoplatforms, and catalytic amplifiers. Moreover, the development of nucleic acid (NA)-responsive intelligent delivery vehicles is a rapidly growing field. These vehicles have attracted much attention in recent years due to their programmable, controllable, and reversible properties. In this work, we review several types of NA-responsive controlled delivery vehicles based on locks and keys, including DNA/RNA-responsive, aptamer-responsive, and CRISPR-responsive, and summarize their advantages and limitations.

中文翻译：

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用于受控货物运输的核酸响应智能系统


刺激响应输送系统可以实现各种货物的受控、高度监管和高效输送，同时最大限度地减少副作用。由于核酸具有独特的性质，包括通过碱基配对采用复杂结构的能力、易于合成、高特异性、形状记忆和可配置性，它们已被应用于自主分子马达、逻辑电路、可重构纳米平台和催化放大器。此外，核酸（NA）响应的智能运载工具的开发是一个快速增长的领域。近年来，这些车辆因其可编程、可控和可逆的特性而备受关注。在这项工作中，我们回顾了几种基于锁和钥匙的NA响应型控制递送载体，包括DNA/RNA响应型、适体响应型和CRISPR响应型，并总结了它们的优点和局限性。