Interest in converting biomass to produce renewable chemicals has increased in recent years. With this category, biomass polyols/aldehydes derived from lignocellulosic refining are cheap materials for preparing high value-added chemicals. Therefore, for the bio-refining, the development of further high-value conversion of biomass polyols/aldehydes is not only conducive to improving the overall economic benefits of bio-refining, but also in line with the sustainable development. However, due to the characteristic of multiple reducing groups in biomass polyols/aldehydes, the selective catalytic oxidation of these groups has become the most challenging obstacle. Contrary to aerobic microorganisms that completely convert carbon sources into water and CO₂, Gluconobacter oxydans shows a great development potential and application prospect with the advantages of incomplete oxidation with regio- and stereo-selectivity. This unique capability, along with its possession of a range of membrane-bound dehydrogenases that enable the production of many high-value-added products. G. oxydans as a privileged non-model microorganism has vigorously advanced the development of bioengineering. In this work, a comprehensive analysis was conducted on the recent advancements in selective catalysis of biomass polyols/aldehydes, providing theoretical guidance and technical support for the biopreparation of lignocellulosic acid and ketone platform compounds by G. oxydans.

近年来，人们对将生物质转化为可再生化学品的兴趣有所增加。在这一类别中，源自木质纤维素精炼的生物质多元醇/醛是用于制备高附加值化学品的廉价材料。因此，对于生物炼制而言，发展生物质多元醇/醛的进一步高值转化不仅有利于提高生物炼制的整体经济效益，而且符合可持续发展。然而，由于生物质多元醇/醛中存在多个还原基团的特点，这些基团的选择性催化氧化已成为最具挑战性的障碍。与将碳源完全转化为水和CO ₂ 的好氧微生物不同，氧化葡糖杆菌以其不完全氧化以及区域和立体选择性的优势，显示出巨大的发展潜力和应用前景。这种独特的能力，加上其拥有一系列膜结合脱氢酶，可以生产许多高附加值产品。 G. oxydans作为一种特有的非模式微生物，有力地推动了生物工程的发展。本工作对生物质多元醇/醛选择性催化的最新进展进行了全面分析，为G. oxydans生物制备木质纤维素酸和酮平台化合物提供理论指导和技术支撑。