Artemisinin is renowned for its various biological activities, particularly its effectiveness against malaria. However, its commercial production is impeded by its low accumulation in . The complexities and high costs associated with chemical synthesis further compound these obstacles. Therefore, this review critically examines recent advancements in artemisinin biosynthesis. By exploring the innovative pathways, the objective is to enhance production efficiency and facilitate accessible and sustainable artemisinin production. Additionally, this review elucidates the environmental influences on artemisinin accumulation and sustainable cultivation practices for . Despite limited CRISPR/Cas9 applications, breakthroughs in metabolic engineering, miRNA regulation, and systems biology offer promising avenues. In this comprehensive discussion, we delve into recent scientific breakthroughs aimed at boosting artemisinin yield while also addressing the challenges and future prospects surrounding its commercial-scale production. By charting a course towards sustainable solutions, it shapes the future of global health interventions of artemisinin and may provide valuable insights for researchers seeking to optimize natural compound production in diverse plant species.

中文翻译：

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青蒿素产业化生产策略：当前进展和未来方向


青蒿素因其多种生物活性而闻名，尤其是其对抗疟疾的功效。然而，其商业化生产因其积累量低而受到阻碍。与化学合成相关的复杂性和高成本进一步加剧了这些障碍。因此，本综述批判性地研究了青蒿素生物合成的最新进展。通过探索创新途径，目标是提高生产效率，促进青蒿素生产的可及性和可持续性。此外，本综述阐明了环境对青蒿素积累和可持续种植实践的影响。尽管 CRISPR/Cas9 的应用有限，但代谢工程、miRNA 调控和系统生物学方面的突破提供了有希望的途径。在这次全面的讨论中，我们深入探讨了旨在提高青蒿素产量的最新科学突破，同时解决了围绕其商业规模生产的挑战和未来前景。通过制定可持续解决方案的路线，它塑造了青蒿素全球健康干预措施的未来，并可能为寻求优化不同植物物种天然化合物生产的研究人员提供宝贵的见解。