A highly selective photocatalytic deuterodefluorination of fluorinated esters with D₂O is presented. By tailoring the catalytic system, a variety of α,α-difluoroaryl acetates underwent selective defluorination/deuteration to afford the 2-fluoro-2-arylacetate-d and 2-arylacetate-d₂ in good yields with excellent deuteration rate. Satisfactorily, this protocol was successfully applied to deuterate some drug molecules, such as the felbinacethyl-d₂ and felbilnac-d₂.

中文翻译：

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光氧化还原催化α,α-二氟芳基乙酸酯和酰胺的选择性氘代脱氟


提出了一种用 D ₂ O 氟化酯的高选择性光催化氘代脱氟反应。通过定制催化体系，多种α,α-二氟芳基乙酸酯进行选择性脱氟/氘化，以良好的产率和优异的产率得到2-氟-2-芳基乙酸酯-d和2-芳基乙酸酯-d ₂ 氘化速率。令人满意的是，该方案成功应用于氘化一些药物分子，例如 felbinacethyl-d ₂ 和 felbilnac-d ₂ 。