A biguanide chitosan-based hydrogel adhesive accelerates the healing of bacterial-infected wounds,Carbohydrate Polymers

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A biguanide chitosan-based hydrogel adhesive accelerates the healing of bacterial-infected wounds
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2024-06-13 , DOI: 10.1016/j.carbpol.2024.122397
Junhao Shi ₁ , Xin Hao ₁ , Hanyu Yang ₁ , Zhimin He ₁ , Jiaju Lu ₁ , Yunhui Li ₂ , Liang Luan ₂ , Quan Zhang ₁

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The development of tissue adhesives with good biocompatibility and potent antimicrobial properties is crucial for addressing the high incidence of surgical site infections in emergency and clinical settings. Herein, an injectable hydrogel adhesive composed of chitosan biguanidine (CSG), oxidized dextran (ODex) and tannin (TA) was synthesized primarily through Schiff-base reactions, hydrogen bonding, and electrostatic interactions. TA was introduced into the CSG/ODex hydrogel to prepare a physicochemically double cross-linked hydrogel. The hydrogel formulation incorporating 2 wt% TA (CSG/ODex-TA2) exhibited rapid gelation, moderate mechanical properties, good tissue adhesion, and sustained release behavior of TA. Both and studies demonstrated that CSG/ODex-TA2 showed significantly enhanced adhesion and antibacterial effectiveness compared to the CSG/ODex hydrogel and commercial fibrin glue. Leveraging the positive charge of CSG, the CSG/ODex-TA2 hydrogel demonstrated a strong contact antibacterial effect, while the sustained release of TA provided diffusion antibacterial capabilities. By integrating contact and diffusion antibacterial mechanisms into the hydrogel, a promising approach was developed to boost antibacterial efficiency and accelerate the healing of wounds infected with methicillin-resistant (). The CSG/ODex-TA2 hydrogel has excellent biocompatibility, hemostatic properties, and antibacterial capabilities, making it a promising candidate for improving wound care and combating bacterial infections.

中文翻译：

基于双胍壳聚糖的水凝胶粘合剂可加速细菌感染伤口的愈合

开发具有良好生物相容性和有效抗菌特性的组织粘合剂对于解决急诊和临床环境中手术部位感染的高发生率至关重要。在此，主要通过席夫碱反应、氢键和静电相互作用合成了由壳聚糖双胍（CSG）、氧化葡聚糖（ODex）和单宁（TA）组成的可注射水凝胶粘合剂。将TA引入CSG/ODex水凝胶中制备物化双交联水凝胶。掺入 2 wt% TA (CSG/ODex-TA2) 的水凝胶制剂表现出快速凝胶化、适度的机械性能、良好的组织粘附性和 TA 的持续释放行为。两项研究均表明，与 CSG/ODex 水凝胶和商业纤维蛋白胶相比，CSG/ODex-TA2 的粘附力和抗菌效果显着增强。利用CSG的正电荷，CSG/ODex-TA2水凝胶表现出很强的接触抗菌作用，而TA的持续释放提供了扩散抗菌能力。通过将接触和扩散抗菌机制整合到水凝胶中，开发了一种有前景的方法来提高抗菌效率并加速耐甲氧西林感染伤口的愈合。 CSG/ODex-TA2水凝胶具有优异的生物相容性、止血特性和抗菌能力，使其成为改善伤口护理和对抗细菌感染的有希望的候选者。

更新日期：2024-06-13

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