Transition metal phosphides with properties similar to platinum metal have received increasing attention for the non-enzymatic detection of glucose. However, the requirement of highly corrosive reagent during sample pretreatment would impose a potential risk to the human body, limiting their practical applications. In this study, we report a self-powered microfluidic device for the non-enzymatic detection of glucose using nickel phosphide (NiP) hybrid as the catalyst. The NiP hybrid is synthesized by pyrolysis of metal-organic framework (MOF)-based precursor and phosphating process, showing two linear detection ranges (1 μM–1 mM, 1 mM–6 mM) toward glucose with the detection limit of 0.32 μM. The good performance of NiP hybrid for glucose is attributed to the synergistic effect of NiP active sites and N-doped porous carbon matrix. The microchip is integrated with a NaOH-loaded paper pad and a capillary-based micropump, enabling the automatic NaOH redissolution and delivery of sample solution into the detection chamber. Under the optimized condition, the NiP hybrid-based microchip realized the detection of glucose in a user-friendly way. Besides, the feasibility of using this microchip for glucose detection in real serum samples has also been validated. This article presents a facile fabrication method utilizing a MOF template to synthesize a NiP hybrid catalyst. By leveraging the synergy between the NiP active sites and the N-doped carbon matrix, an exceptional electrochemical detection performance for glucose has been achieved. Additionally, a self-powered chip device has been developed for convenient glucose detection based on the pre-established high pH environment on the chip.

中文翻译：

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集成磷化镍混合修饰电极的毛细管驱动微芯片用于电化学检测葡萄糖


具有与铂金属相似性质的过渡金属磷化物在葡萄糖的非酶检测中受到越来越多的关注。然而，样品前处理过程中需要使用高腐蚀性试剂，这会对人体造成潜在风险，限制了其实际应用。在这项研究中，我们报告了一种自供电微流体装置，用于使用磷化镍（NiP）杂化物作为催化剂对葡萄糖进行非酶检测。 NiP 杂化物是通过基于金属有机框架 (MOF) 的前体热解和磷化过程合成的，对葡萄糖显示出两个线性检测范围 (1 µM–1 mM、1 mM–6 mM)，检测限为 0.32 µM。 NiP杂化物对葡萄糖的良好性能归因于NiP活性位点和氮掺杂多孔碳基质的协同作用。该微芯片与装载 NaOH 的纸垫和基于毛细管的微泵集成，能够自动重新溶解 NaOH 并将样品溶液输送到检测室中。在优化的条件下，基于NiP混合的微芯片以用户友好的方式实现了葡萄糖的检测。此外，利用该微芯片检测真实血清样本中的葡萄糖的可行性也得到了验证。本文提出了一种利用 MOF 模板合成 NiP 混合催化剂的简便制造方法。通过利用 NiP 活性位点和 N 掺杂碳基质之间的协同作用，实现了卓越的葡萄糖电化学检测性能。此外，还开发了一种自供电芯片装置，基于芯片上预先建立的高pH环境，可以方便地进行葡萄糖检测。