Grape pomace, the solid residue produced during fruit extraction, is a significant by-product of the wine industry. The industry generates vast amounts of grape pomace each year, causing environmental concerns. Despite its immense potential as a source of bioactive compounds, grape pomace is mostly disposed of, with only a tiny portion used as animal feed. Numerous studies highlight the capability of microorganisms, especially filamentous fungi, that can convert grape pomace into various value-added products. In particular, the , , and genera are renowned for their capacity to release lignocellulolytic enzymes that allow the conversion of sugars into valuable compounds with extensive applications. This review article introduces innovative microbial valorisation techniques to extract beneficial compounds for use in the nutraceutical, cosmetic, and therapeutic industries. Furthermore, the potential implementation of a circular economy model and essential strategies to mitigate the environmental implications of grape pomace disposal are also discussed.

中文翻译：

---

变废为宝：基于微生物的葡萄渣增值，用于营养保健品、化妆品和治疗应用，以促进循环经济


葡萄渣是水果提取过程中产生的固体残留物，是葡萄酒工业的重要副产品。该行业每年产生大量葡萄渣，引起环境问题。尽管葡萄渣作为生物活性化合物的来源具有巨大的潜力，但大部分都被丢弃，只有一小部分用作动物饲料。许多研究强调了微生物，尤其是丝状真菌的能力，可以将葡萄渣转化为各种增值产品。特别是， 、 和 属因其释放木质纤维素分解酶的能力而闻名，这些酶可以将糖转化为具有广泛应用的有价值的化合物。这篇综述文章介绍了创新的微生物增值技术，用于提取有益化合物用于营养保健品、化妆品和治疗行业。此外，还讨论了循环经济模型的潜在实施以及减轻葡萄渣处理对环境影响的基本策略。