The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases,Matrix Biology

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The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases
Matrix Biology ( IF 4.5 ) Pub Date : 2024-06-11 , DOI: 10.1016/j.matbio.2024.06.003
Federica Genovese ₁ , Cecilie Bager ₁ , Peder Frederiksen ₁ , Dario Vazquez ₁ , Jannie Marie Bülow Sand ₁ , R Gisli Jenkins ₂ , Toby M Maher ₃ , Iain D Stewart ₂ , Philip L Molyneaux ₂ , William A Fahy ₄ , Louise V Wain ₅ , Jørgen Vestbo ₆ , Carmel Nanthakumar ₇ , Saher Burhan Shaker ₈ , Nils Hoyer ₈ , Diana Julie Leeming ₁ , Jacob George ₉ , Jonel Trebicka ₁₀ , Daniel Guldager Kring Rasmussen ₁ , Michael K Hansen ₁₁ , Paul Cockwell ₁₂ , Daan Kremer ₁₃ , Stephan Jl Bakker ₁₃ , Nicholas M Selby ₁₄ , Alexander Lynge Reese-Petersen ₁ , Arantxa González ₁₅ , Julio Núñez ₁₆ , Peter Rossing ₁₇ , Neel I Nissen ₁ , Mogens Karsbøl Boisen ₁₈ , Inna M Chen ₁₈ , Lei Zhao ₁₉ , Morten A Karsdal ₁ , Detlef Schuppan ₂₀

Affiliation

Nordic Bioscience A/S, Herlev, Denmark.
Imperial College London 4615, National Heart & Lung Institute, London, UK.
Keck Medicine of University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA.
Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK; Department of Population Health Sciences, University of Leicester, Leicester, UK.
Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, England.
Clinical Sciences (Respiratory), GSK Research & Development, GSKH, Brentford, UK.
Department of Respiratory Medicine, Gentofte University Hospital, Hellerup, Hovedstaden, Denmark.
Storr Liver Centre, The Westmead Institute for Medical Research and Westmead Hospital, University of Sydney, Sydney, NSW, Australia.
Medizinische Klinik B, Universitätsklinikum Münster, Münster University, Münster, Germany.
Janssen Research & Development, LLC, Spring House, PA, USA.
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Department of Internal Medicine, University Medical Center Groningen, University of Groningen 9713 GZ, Groningen, The Netherlands.
Department of Renal Medicine, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA 31008, Pamplona, Spain; Centro de investigacion biomedica en red enfermedades cardiovasculares, Madrid, Spain.
Department of Cardiology, Hospital Clínico Universitario de Valencia (INCLIVA), Valencia, Spain.
Steno Diabetes Center Copenhagen, Herlev, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Bristol-Myers Squibb Company, Lawrenceville, New Jersey, USA.
Institute of Translational Immunology and Research Center for Immune Therapy, University Medical Center, Mainz, Germany.

Fibrosis, driven by fibroblast activities, is an important contributor to morbidity and mortality in most chronic diseases. Endotrophin, a signaling molecule derived from processing of type VI collagen by highly activated fibroblasts, is involved in fibrotic tissue remodeling. Circulating levels of endotrophin have been associated with an increased risk of mortality in multiple chronic diseases.

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