Germ cell tumors (GCT) are the most common solid tumors in young men of age 15 - 40. In previous studies, we profiled the interaction of GCT cells with cells of the tumor microenvironment (TM), which showed that especially the 3D interaction of fibroblasts (FB) or macrophages with GCT cells influenced the growth behavior and cisplatin response as well as the transcriptome and secretome of the tumor cells, suggesting that the crosstalk of these cells with GCT cells is crucial for tumor progression and therapy outcome.

中文翻译：

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睾丸癌相关成纤维细胞的分子和表观遗传学离体分析及其与生殖细胞肿瘤细胞和巨噬细胞的相互作用


生殖细胞肿瘤 (GCT) 是 15 - 40 岁年轻男性中最常见的实体瘤。在之前的研究中，我们分析了 GCT 细胞与肿瘤微环境 (TM) 细胞的相互作用，结果表明，尤其是 3D 相互作用成纤维细胞 (FB) 或巨噬细胞与 GCT 细胞影响肿瘤细胞的生长行为和顺铂反应以及转录组和分泌组，表明这些细胞与 GCT 细胞的串扰对于肿瘤进展和治疗结果至关重要。