Ferroptosis in health and disease,Redox Biology

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Ferroptosis in health and disease
Redox Biology ( IF 10.7 ) Pub Date : 2024-05-30 , DOI: 10.1016/j.redox.2024.103211
Carsten Berndt ₁ , Hamed Alborzinia ₂ , Vera Skafar Amen ₃ , Scott Ayton ₄ , Uladzimir Barayeu ₅ , Alexander Bartelt ₆ , Hülya Bayir ₇ , Christina M Bebber ₈ , Kivanc Birsoy ₉ , Jan P Böttcher ₁₀ , Simone Brabletz ₁₁ , Thomas Brabletz ₁₁ , Ashley R Brown ₁₂ , Bernhard Brüne ₁₃ , Giorgia Bulli ₁₄ , Alix Bruneau ₁₅ , Quan Chen ₁₆ , Gina M DeNicola ₁₇ , Tobias P Dick ₁₈ , Ayelén Distéfano ₁₉ , Scott J Dixon ₂₀ , Jan B Engler ₂₁ , Julia Esser-von Bieren ₂₂ , Maria Fedorova ₂₃ , José Pedro Friedmann Angeli ₃ , Manuel A Friese ₂₁ , Dominic C Fuhrmann ₁₃ , Ana J García-Sáez ₂₄ , Karolina Garbowicz ₂₅ , Magdalena Götz ₂₆ , Wei Gu ₂₇ , Linda Hammerich ₁₅ , Behrouz Hassannia ₂₈ , Xuejun Jiang ₂₉ , Aicha Jeridi ₃₀ , Yun Pyo Kang ₃₁ , Valerian E Kagan ₃₂ , David B Konrad ₃₃ , Stefan Kotschi ₃₄ , Peng Lei ₃₅ , Marlène Le Tertre ₃₆ , Sima Lev ₃₇ , Deguang Liang ₂₉ , Andreas Linkermann ₃₈ , Carolin Lohr ₃₉ , Svenja Lorenz ₄₀ , Tom Luedde ₃₉ , Axel Methner ₄₁ , Bernhard Michalke ₄₂ , Anna V Milton ₃₃ , Junxia Min ₄₃ , Eikan Mishima ₄₀ , Sebastian Müller ₄₄ , Hozumi Motohashi ₄₅ , Martina U Muckenthaler ₃₆ , Shohei Murakami ₄₅ , James A Olzmann ₄₆ , Gabriela Pagnussat ₁₉ , Zijan Pan ₄₇ , Thales Papagiannakopoulos ₄₈ , Lohans Pedrera Puentes ₄₉ , Derek A Pratt ₅₀ , Bettina Proneth ₄₀ , Lukas Ramsauer ₁₀ , Raphael Rodriguez ₄₄ , Yoshiro Saito ₅₁ , Felix Schmidt ₄₁ , Carina Schmitt ₃₃ , Almut Schulze ₅₂ , Annemarie Schwab ₁₁ , Anna Schwantes ₁₃ , Mariluz Soula ₉ , Benedikt Spitzlberger ₅₃ , Brent R Stockwell ₅₄ , Leonie Thewes ₁ , Oliver Thorn-Seshold ₃₃ , Shinya Toyokuni ₅₅ , Wulf Tonnus ₅₆ , Andreas Trumpp ₅₇ , Peter Vandenabeele ₅₈ , Tom Vanden Berghe ₅₉ , Vivek Venkataramani ₆₀ , Felix C E Vogel ₅₂ , Silvia von Karstedt ₆₁ , Fudi Wang ₄₃ , Frank Westermann ₂₅ , Chantal Wientjens ₆₂ , Christoph Wilhelm ₆₂ , Michele Wölk ₂₃ , Katherine Wu ₄₈ , Xin Yang ₆₃ , Fan Yu ₁₆ , Yilong Zou ₆₄ , Marcus Conrad ₄₀

Affiliation

Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia.
Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany; Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
Department of Pediatrics, Columbia University, New York City, NY, USA.
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA.
Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany.
Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany.
Department of Biological Sciences, Columbia University, New York City, NY, USA.
Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany.
Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany.
Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany.
College of Life Sciences, Nankai University, Tianjin, China.
Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA.
Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.
Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina.
Department of Biology, Stanford University, Stanford, CA, USA.
Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany.
Department of Immunobiology, Université de Lausanne, Switzerland.
Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany.
Institute for Genetics, CECAD, University of Cologne, Germany; Max Planck Institute of Biophysics, Frankfurt/Main, Germany.
Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany.
Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center Munich, Germany.
Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Department of Biomedical Sciences, University of Antwerp, Belgium.
Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany, Member of the German Center for Lung Research (DZL).
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Republic of Korea.
School of Public Health, University of Pittsburgh, PA, USA.
Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany.
Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Center for Translational Biomedical Iron Research, Heidelberg University, Germany.
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.
Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany.
Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany.
Research Unit Analytical Biogeochemistry, Helmholtz Center Munich, Germany.
School of Medicine, Zhejiang University, Hangzhou, China.
Cellular and Chemical Biology, Institut Curie, Paris, France.
Department of Gene Expression Regulation, Tohoku University, Sendai, Japan.
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
School of Life Sciences, Westlake University, Hangzhou, China.
Department of Pathology, Grossman School of Medicine, New York University, NY, USA.
Institute for Genetics, CECAD, University of Cologne, Germany.
Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada.
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Division of Tumour Metabolism and Microenvironment, DKFZ Heidelberg and DKFZ-ZMBH Alliance, Heidelberg, Germany.
Department of Immunobiology, Université de Lausanne, Switzerland; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Munich, Germany.
Department of Biological Sciences, Columbia University, New York City, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Chemistry, Columbia University, New York, NY, USA.
Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan; Center for Integrated Sciences of Low-temperature Plasma Core Research (iPlasma Core), Tokai National Higher Education and Research System, Nagoya, Japan.
Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.
Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany.
VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Department of Biomedical Sciences, University of Antwerp, Belgium; VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Germany.
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Germany.
Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Germany.
Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
School of Life Sciences, Westlake University, Hangzhou, China; Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to rupture of the plasma membrane. Ferroptosis is unique in that it is essentially a spontaneous, uncatalyzed chemical process based on perturbed iron and redox homeostasis contributing to the cell death process, but that it is nonetheless modulated by many metabolic nodes that impinge on the cells’ susceptibility to ferroptosis. Among the various nodes affecting ferroptosis sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets for the treatment of numerous currently incurable diseases. Herein, the current members of a Germany-wide research consortium focusing on ferroptosis research, as well as key external experts in ferroptosis who have made seminal contributions to this rapidly growing and exciting field of research, have gathered to provide a comprehensive, state-of-the-art review on ferroptosis. Specific topics include: basic mechanisms, relevance, specialized methodologies, chemical and pharmacological tools, and the potential contribution of ferroptosis to disease etiopathology and progression. We hope that this article will not only provide established scientists and newcomers to the field with an overview of the multiple facets of ferroptosis, but also encourage additional efforts to characterize further molecular pathways modulating ferroptosis, with the ultimate goal to develop novel pharmacotherapies to tackle the various diseases associated with – or caused by – ferroptosis.

中文翻译：

健康和疾病中的铁死亡

铁死亡是一种普遍的非凋亡形式的细胞死亡，与各种退行性疾病和恶性肿瘤高度相关。铁死亡的标志是膜磷脂中含有的多不饱和脂肪酸不受控制和压倒性的过氧化，最终导致质膜破裂。铁死亡的独特之处在于，它本质上是一种自发的、非催化的化学过程，基于扰动的铁和氧化还原稳态，导致细胞死亡过程，但它仍然受到许多影响细胞对铁死亡的易感性的代谢节点的调节。在影响铁死亡敏感性的各种节点中，有几个节点已成为药物干预的有希望的候选者，使铁死亡相关蛋白成为治疗许多目前无法治愈的疾病的有吸引力的靶标。在此，专注于铁死亡研究的德国研究联盟的现任成员，以及铁死亡领域的主要外部专家，他们为这个快速发展和令人兴奋的研究领域做出了开创性的贡献，他们聚集在一起，提供了全面的、最新的研究成果。 -铁死亡的最新评论。具体主题包括：基本机制、相关性、专门方法、化学和药理学工具，以及铁死亡对疾病病因病理学和进展的潜在贡献。我们希望本文不仅能为该领域的知名科学家和新人提供铁死亡的多个方面的概述，而且鼓励进一步努力来表征调节铁死亡的进一步分子途径，最终目标是开发新的药物疗法来解决铁死亡的问题。与铁死亡相关或由铁死亡引起的各种疾病。

更新日期：2024-05-30

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