Pyrogallol, a botanical hydrolysable tannin, has diverse medical and industrial applications. Its impact on aquatic ecosystems and fish health has been previously studied, revealing histopathological, immunological, biochemical, and haematological alterations in African catfish (). In this study, the neurotoxic potential of pyrogallol was assessed through a 15-day exposure of catfish to concentrations of 1, 5, or 10 mg/L. Enzyme activities such as acetylcholinesterase (AchE), monoamine oxidase (MAO), aldehyde oxidase (AO), and nitric oxide (NO) were measured in serum and brain, along with histopathological examinations in the brain and heart. Pyrogallol exposure led to decreased AchE activity in the brain and serum, increased serum MAO activity, elevated AO in both brain and serum, and suppressed NO levels. Morphological abnormalities and dose-dependent pathological alterations were observed in the brain and heart, including neuropile deformities, shrunken Purkinje cells, cardiomyocyte degeneration, and increased collagen fibers. This suggests that pyrogallol induces adverse effects in fish.

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连苯三酚对鲶鱼（Clarias gariepinus）的神经毒性和心脏毒性作用


连苯三酚是一种植物可水解单宁，具有多种医疗和工业应用。之前已经研究过它对水生生态系统和鱼类健康的影响，揭示了非洲鲶鱼的组织病理学、免疫学、生化和血液学变化。在这项研究中，通过将鲶鱼暴露在浓度为 1、5 或 10 mg/L 的环境中 15 天，评估了连苯三酚的神经毒性潜力。测量血清和大脑中的乙酰胆碱酯酶（AchE）、单胺氧化酶（MAO）、乙醛氧化酶（AO）和一氧化氮（NO）等酶活性，并对大脑和心脏进行组织病理学检查。暴露于邻苯三酚会导致大脑和血清中的 AchE 活性降低，血清 MAO 活性增加，大脑和血清中的 AO 升高，并抑制 NO 水平。在大脑和心脏中观察到形态异常和剂量依赖性病理改变，包括神经桩畸形、浦肯野细胞萎缩、心肌细胞变性和胶原纤维增加。这表明连苯三酚会对鱼类产生不利影响。