In aging, physiologic networks decline in function at rates that differ between individuals, producing a wide distribution of lifespan. Though 70% of human lifespan variance remains unexplained by heritable factors, little is known about the intrinsic sources of physiologic heterogeneity in aging. To understand how complex physiologic networks generate lifespan variation, new methods are needed.

中文翻译：

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利用群体异步性系统绘制衰老过程中生物体规模的基因调控网络


在衰老过程中，生理网络功能衰退的速度因人而异，从而产生了广泛的寿命分布。尽管人类寿命差异的 70% 仍然无法用遗传因素来解释，但人们对衰老过程中生理异质性的内在根源知之甚少。为了了解复杂的生理网络如何产生寿命变化，需要新的方法。