Some thermal degradants of curcuminoids have demonstrated moderate health benefits in previous studies. Feruloyl acetone (FER), recently identified as a thermal degradant of curcumin, has been previously associated with anticancer and antioxidative effects, yet its other capabilities remain unexplored. Moreover, earlier reports suggest that methoxy groups on the aromatic ring may influence the functionality of the curcuminoids. To address these gaps, an animal study was conducted to investigate the antiobesity effects of both FER and its demethoxy counterpart (DFER) on mice subjected to a high-fat diet. The results demonstrated the significant prevention of weight gain and enlargement of the liver and various adipose tissues by both samples. Furthermore, these supplements exhibited a lipid regulatory effect in the liver through the adiponectin/AMPK/SIRT1 pathway, promoted thermogenesis via AMPK/PGC-1α activation, and positively influenced gut-microbial-produced short-chain fatty acid (SCFA) levels. Notably, DFER demonstrated superior overall efficacy in combating obesity, while FER displayed a significant effect in modulating inflammatory responses. It is considered that SCFA may be responsible for the distinct effects of FER and DFER in the animal study. Future studies are anticipated to delve into the efficacy of curcuminoid degradants, encompassing toxicity and pharmacokinetic evaluations.

中文翻译：

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姜黄素降解物的结构差异：对小鼠肥胖的影响


在之前的研究中，姜黄素的一些热降解物已证明具有一定的健康益处。阿魏酰丙酮 (FER) 最近被确定为姜黄素的热降解剂，之前已被认为具有抗癌和抗氧化作用，但其其他功能仍未被探索。此外，早期的报告表明芳环上的甲氧基可能会影响类姜黄素的功能。为了解决这些差距，我们进行了一项动物研究，以研究 FER 及其去甲氧基对应物 (DFER) 对高脂肪饮食小鼠的抗肥胖作用。结果表明，两种样品均能显着防止体重增加以及肝脏和各种脂肪组织的增大。此外，这些补充剂通过脂联素/AMPK/SIRT1途径在肝脏中表现出脂质调节作用，通过AMPK/PGC-1α激活促进产热，并对肠道微生物产生的短链脂肪酸（SCFA）水平产生积极影响。值得注意的是，DFER 在对抗肥胖方面表现出卓越的整体功效，而 FER 在调节炎症反应方面表现出显着效果。在动物研究中，人们认为 SCFA 可能是 FER 和 DFER 的不同作用的原因。未来的研究预计将深入研究类姜黄素降解物的功效，包括毒性和药代动力学评估。