To monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 inhibition as disease-modifying therapy of knee osteoarthritis, and to investigate relationships between reduction in ARGS and change in cartilage thickness, knee-related pain and function.

中文翻译：

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针对骨关节炎的 2 期临床试验中的血清 ARGS-聚集蛋白聚糖


在具有血小板反应蛋白基序 （ADAMTS）-5 抑制的解整合素和金属蛋白酶作为膝骨关节炎疾病缓解疗法的临床试验中监测聚集蛋白聚糖丙氨酸-精氨酸-甘氨酸-丝氨酸 （ARGS） 新表位的血清浓度，并研究 ARGS 降低与软骨厚度变化、膝关节相关疼痛和功能之间的关系。