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Unambiguous Characterization of Commercial Natural (Dihydro)phenanthrene Compounds Is Vital in the Discovery of AMPK Activators
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-06-19 , DOI: 10.1021/acs.jafc.4c01616 Denis Barron 1 , Yann Ratinaud 1 , Simona Rambousek 1 , Benjamin Brinon 1 , Martine Naranjo Pinta 1 , Matthew J Sanders 1 , Kei Sakamoto 1 , Olivier Ciclet 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-06-19 , DOI: 10.1021/acs.jafc.4c01616 Denis Barron 1 , Yann Ratinaud 1 , Simona Rambousek 1 , Benjamin Brinon 1 , Martine Naranjo Pinta 1 , Matthew J Sanders 1 , Kei Sakamoto 1 , Olivier Ciclet 1
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These days, easy access to commercially available (poly)phenolic compounds has expanded the scope of potential research beyond the field of chemistry, particularly in the area of their bioactivity. However, the quality of these compounds is often overlooked or not even considered. This issue is illustrated in this study through the example of (dihydro)phenanthrenes, a group of natural products present in yams, as AMP-activated protein kinase (AMPK) activators. A study conducted in our group on a series of compounds, fully characterized using a combination of chemical synthesis, NMR and MS techniques, provided evidence that the conclusions of a previous study were erroneous, likely due to the use of a misidentified commercial compound by its supplier. Furthermore, we demonstrated that additional representatives of the (dihydro)phenanthrene phytochemical classes were able to directly activate AMPK, avoiding the risk of misinterpretation of results based on analysis of a single compound alone.
中文翻译：
商业天然（二氢）菲化合物的明确表征对于 AMPK 激活剂的发现至关重要
如今，可轻松获得市售的（多）酚化合物已将潜在研究范围扩大到化学领域之外，特别是在其生物活性领域。然而，这些化合物的质量常常被忽视甚至不被考虑。本研究通过（二氢）菲（山药中存在的一组天然产物）作为 AMP 激活蛋白激酶 (AMPK) 激活剂的例子说明了这个问题。我们小组对一系列化合物进行了一项研究，利用化学合成、核磁共振和质谱技术的组合进行了全面表征，提供了证据表明先前研究的结论是错误的，可能是由于其使用了错误识别的商业化合物。供应商。此外，我们证明了（二氢）菲植物化学类别的其他代表能够直接激活 AMPK，避免了基于单独分析单一化合物而误解结果的风险。
更新日期：2024-06-19
中文翻译：
商业天然（二氢）菲化合物的明确表征对于 AMPK 激活剂的发现至关重要
如今，可轻松获得市售的（多）酚化合物已将潜在研究范围扩大到化学领域之外，特别是在其生物活性领域。然而，这些化合物的质量常常被忽视甚至不被考虑。本研究通过（二氢）菲（山药中存在的一组天然产物）作为 AMP 激活蛋白激酶 (AMPK) 激活剂的例子说明了这个问题。我们小组对一系列化合物进行了一项研究，利用化学合成、核磁共振和质谱技术的组合进行了全面表征，提供了证据表明先前研究的结论是错误的，可能是由于其使用了错误识别的商业化合物。供应商。此外，我们证明了（二氢）菲植物化学类别的其他代表能够直接激活 AMPK，避免了基于单独分析单一化合物而误解结果的风险。
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