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Driving the wedge: Understanding an improved Cas9 to better engineer others
Molecular Cell ( IF 14.5 ) Pub Date : 2024-06-20 , DOI: 10.1016/j.molcel.2024.05.026 Charles J Lenihan 1 , Scott Bailey 2
中文翻译:
推动楔子:了解改进的 Cas9 以更好地设计其他产品
更新日期:2024-06-20
Molecular Cell ( IF 14.5 ) Pub Date : 2024-06-20 , DOI: 10.1016/j.molcel.2024.05.026 Charles J Lenihan 1 , Scott Bailey 2
Affiliation
In their recent structural work, Eggers et al.1 rationalize how key mutations in the WED domain of the compact and thermostable Geobacillus stearothermophilus Cas9 bolster its editing efficiency in mammalian cells, and they use these insights to rationally improve another Cas9.
中文翻译:
推动楔子:了解改进的 Cas9 以更好地设计其他产品
在他们最近的结构工作中,Eggers 等人。 1合理解释了紧凑且热稳定的嗜热脂肪地芽孢杆菌Cas9 的 WED 结构域中的关键突变如何增强其在哺乳动物细胞中的编辑效率,并且他们利用这些见解合理地改进了另一个 Cas9。