Velcrins are molecular glues that induce complex formation between PDE3A and SLFN12. The PDE3A-SLFN12 complex activates the SLFN12 RNase, resulting in cleavage of the specific substrate, tRNA-Leu-TAA, global inhibition of translation, and death of cells expressing sufficient levels of both proteins. Here, unanswered questions about the mechanism of action and therapeutic promise of velcrin compounds are discussed.

中文翻译：

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Velcrin 化合物激活 SLFN12 tRNase 以诱导脊髓凋亡


Velcrins 是诱导 PDE3A 和 SLFN12 之间形成复合物的分子胶。PDE3A-SLFN12 复合物激活 SLFN12 RNase，导致特异性底物 tRNA-Leu-TAA 裂解、翻译整体抑制和表达两种蛋白水平足够水平的细胞死亡。在这里，讨论了有关 velcrin 化合物的作用机制和治疗前景的未解之谜。