Velcrins are molecular glues that induce complex formation between PDE3A and SLFN12. The PDE3A-SLFN12 complex activates the SLFN12 RNase, resulting in cleavage of the specific substrate, tRNA-Leu-TAA, global inhibition of translation, and death of cells expressing sufficient levels of both proteins. Here, unanswered questions about the mechanism of action and therapeutic promise of velcrin compounds are discussed.

中文翻译：

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Velcrin 化合物激活 SLFN12 tRNase 诱导断层下垂

Velcrins 是一种分子胶，可诱导 PDE3A 和 SLFN12 之间形成复合物。 PDE3A-SLFN12 复合物激活 SLFN12 RNase，导致特定底物 tRNA-Leu-TAA 的裂解、翻译的全局抑制以及表达足够水平的两种蛋白的细胞死亡。在此，讨论了有关 Velcrin 化合物的作用机制和治疗前景的未解答问题。