Pharmacological modulation of the Wnt/β-catenin signaling pathway holds promises for both basic research and therapeutic applications. In this issue of Cell Chemical Biology, Kschonsak et al.1 engineered knotted peptides that promote Wnt signaling by targeting ZNRF3 and serve as pharmacological tools for studying Wnt biology and supporting organoid growth.

中文翻译：

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使用新的 Wnt 信号转导激动剂让您的受体打结


Wnt/β-catenin 信号通路的药理学调节有望用于基础研究和治疗应用。在本期《细胞化学生物学》中，Kschonsak 等人1 设计了打结肽，通过靶向 ZNRF3 促进 Wnt 信号传导，并作为研究 Wnt 生物学和支持类器官生长的药理学工具。