Pharmacological modulation of the Wnt/β-catenin signaling pathway holds promises for both basic research and therapeutic applications. In this issue of Cell Chemical Biology, Kschonsak et al.¹ engineered knotted peptides that promote Wnt signaling by targeting ZNRF3 and serve as pharmacological tools for studying Wnt biology and supporting organoid growth.

中文翻译：

---

使用新型 Wnt 信号激动剂让您的受体打结

Wnt/β-连环蛋白信号通路的药理学调节为基础研究和治疗应用带来了希望。在本期《细胞化学生物学》中，Kschonsak 等人。 ¹ 工程化打结肽通过靶向 ZNRF3 促进 Wnt 信号传导，并作为研究 Wnt 生物学和支持类器官生长的药理学工具。