Numerous studies have evaluated the gut microbiome as a biomarker for predicting cancer immunotherapy, but the heterogeneity among different studies has hindered its applications. In this issue of Cell, Derosa et al. report a biomarker based on the ecological topology of the gut microbiota that can predict immunotherapy efficacy effectively.

中文翻译：

---

肠道微生物组生态拓扑作为癌症免疫治疗的下一代生物标志物

许多研究评估了肠道微生物组作为预测癌症免疫治疗的生物标志物，但不同研究之间的异质性阻碍了其应用。在本期《细胞》中， Derosa 等人。报告了一种基于肠道微生物群生态拓扑的生物标志物，可以有效预测免疫治疗效果。